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KMID : 0923620210210060041
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Immune Network
2021 Volume.21 No. 6 p.41 ~ p.41
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Correlation between Reactogenicity and Immunogenicity after the ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccination
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Lim So-Yun
Kim Ji-Yeun
Park Soon-Ju
Kwon Ji-Soo
Park Ji-Young
Cha Hye-Hee
Suh Mi-Hyun
Lee Hyun-Jung
Lim Joon-Seo
Bae Seong-Man
Jung Ji-Won
Lee Na-Kyung
Kim Ki-Deok
Shum David
Jee Young-Mee
Kim Sung-Han
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Abstract
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Correlation between vaccine reactogenicity and immunogenicity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Thus, we investigated to determine whether the reactogenicity after coronavirus disease 2019 vaccination is associated with antibody (Ab) titers and T cell responses. This study was prospective cohort study done with 131 healthcare workers at tertiary center in Seoul, South Korea. The degrees of the local reactions after the 1st and 2nd doses of ChAdOx1 nCov-19 (ChAdOx1) vaccination were significantly associated with the S1-specific IgG Ab titers (p=0.003 and 0.01, respectively) and neutralizing Ab (p=0.04 and 0.10, respectively) in age- and sex-adjusted multivariate analysis, whereas those after the BNT162b2 vaccination did not show significant associations. T cell responses did not show significant associations with the degree of reactogenicity after the ChAdOx1 vaccination or the BNT162b2 vaccination. Thus, high degree of local reactogenicity after the ChAdOx1 vaccine may be used as an indicator of strong humoral immune responses against SARS-CoV-2.
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KEYWORD
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COVID-19, Vaccine, Antibody response, Neutralizing antibody, Injection site reaction
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